Elucidating host cell response pathways and repurposing therapeutics for SARS-CoV-2 and other coronavirusesArticle Published on 2022-11-052022-11-15 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] Analysis common cold Coronaviruses Compound COVID-19 COVID-19 therapeutics cytotoxicity effective gene expression profile globe Heat shock homoharringtonine host cell response host response in silico in vitro modulating other coronavirus pandemic pathway Prevent provided reported SARS-CoV-2 SARS-CoV-2 biology screened severe symptoms tanespimycin target tested unique Vaccine viral infection [DOI] 10.1038/s41598-022-21984-w PMC 바로가기
SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived CellsArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] activate Activation activities activity acute respiratory syndrome betacoronaviruses Cell cellular change coronavirus coronavirus country Critical death downstream Endoplasmic reticulum enzyme ER stress examined expression of gene functions Gene Expression HCoV-OC43 Host host cell host cells host immune system Human human cell human cells imperative individual induce infect Infection inhibit interact IRE1α pathway less limit MERS-CoV MHV Middle East molecular mechanism mRNA murine OC43 Other other coronavirus pathway Prevent processed Replication required Respiratory Coronavirus respiratory syndrome coronavirus Reticulum RNase SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe respiratory disease signaling pathway similarity splice Spread Stress tested the interferon transcription factor Trigger unfolded protein response Unfolded protein response. UPR Vaccine viral replication virus XBP1 [DOI] 10.1128/mbio.02415-22 PMC 바로가기
FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronavirusesArticle Published on 2022-09-012022-11-15 Journal: Journal of Lipid Research [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Cell click chemistry conserved coronavirus CoV CoV-229E Critical cysteine de novo enzyme epithelial cells examined expressed FASN fatty Fatty acid host cell Host cell entry human coronavirus in vitro incubated Infection inhibited inhibitor isoform Modification modify Multiple other coronavirus palmitate phylogenetically Prevent Protein reduction in reported residues S-acylation SARS-CoV-2 specificity spike coronavirus. Spike protein Spread the spike protein ZDHHC ZDHHC5 [DOI] 10.1016/j.jlr.2022.100256 PMC 바로가기
Autoantibodies in COVID-19 correlate with antiviral humoral responses and distinct immune signaturesCOVID-19의 자가항체는 항바이러스 체액 반응 및 뚜렷한 면역 신호와 상관관계가 있습니다Article Published on 2022-08-012022-09-11 Journal: Allergy [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료기술, 치료제, [키워드] acute COVID-19 acute disease acute SARS-CoV-2 infection alteration antibody Antibody titer Antibody titers antineutrophil cytoplasmic antibodies antinuclear antibodies Antiviral association autoantibodies autoantibodies. autoantibody Autoimmune autoimmune pathology B-cell breadth clinically Cohort Comorbidities comparable controls coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients cross-reactive cytoplasmic demonstrated detect disease disease course exhibited feature healthy controls humoral immune response Humoral response humoral responses immune immune responses immune signature Immunity immunofluorescence assay implication indirect immunofluorescence individual Infection Inflammatory occur other coronavirus other coronaviruses Paired analysis Patient patients performed Prevalence proteomics SARS-CoV-2 screened serological serum severe COVID-19 severity of COVID-19 subgroup of patient trajectory vaccinated individuals VirScan [DOI] 10.1111/all.15302 PMC 바로가기 [Article Type] Article
The double-membrane vesicle (DMV): a virus-induced organelle dedicated to the replication of SARS-CoV-2 and other positive-sense single-stranded RNA viruses이중막 소포(DMV): SARS-CoV-2 및 기타 포지티브 센스 단일 가닥 RNA 바이러스 복제 전용 바이러스 유도 소기관Review Published on 2022-07-162022-09-11 Journal: Cellular and Molecular Life Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analogy Antiviral approach autophagic biogenesis can not Cell organelle coronavirus COVID-19 Double-membrane vesicle Endoplasmic reticulum export Genome Golgi apparatus HCV hepatitis C hepatitis C virus host cell host cell membrane host cell membranes induce initial Innate immunity interactions involved lipid droplet lipid droplets lipids mechanism mechanisms membrane metabolite metabolites Mitochondria morphology non-structural protein organelle other coronavirus other coronaviruses pathogen phylogenetically positive-sense single-stranded RNA Positive-sense single-stranded RNA virus Replication replication of SARS-CoV-2 Replication organelle required RNA RNA virus SARS-CoV-2 sealed shown similarity single-stranded storage supply these viruses Vesicle viral replication Viral RNA virions virus Virus/cell interactions. viruses [DOI] 10.1007/s00018-022-04469-x PMC 바로가기 [Article Type] Review
SARS-CoV-2 and the NucleusSARS-CoV-2와 핵Review Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] blocked caused cells cilia Clinical studies contribute COVID-19 pandemic Critical cytoplasm DNA DNA damage Epigenetic epigenetics Genome greatly reduce immune responses inhibitor innate immune responses Innate immunity lack life cycle mechanisms metabolism mRNA metabolism nuclear nuclear translocation nuclear transport. nucleus other coronavirus other coronaviruses pathway Pathways pharmacological Regulation replicated RNA virus rupture SARS-CoV-2 small molecule small molecule drug small molecule drugs Therapeutic treatment Transport virus infection virus replication [DOI] 10.7150/ijbs.72482 PMC 바로가기 [Article Type] Review
COVID-19 vaccination elicits an evolving, cross-reactive antibody response to epitopes conserved with endemic coronavirus spike proteinsCOVID-19 백신 접종은 고유의 코로나바이러스 스파이크 단백질로 보존된 에피토프에 대한 진화하는 교차 반응성 항체 반응을 이끌어냅니다Article Published on 2022-07-052022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] Alanine antibody conserved coronavirus coronavirus spike protein CoV COVID-19 pandemic COVID-19 vaccination CoVs CP: Immunology CP: Microbiology cross-reactive cross-reactive antibody detectable elicit Endemic epitope Epitopes experiments homolog identify Immunity immunology longitudinal samples mechanism Microbiology mRNA mRNA-1273 mRNA-1273 vaccine multiplexed serology observé other coronavirus other coronaviruses phylogenetically reactivity regions residue SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes serology spike subject the vaccine trajectory triggered vaccination vaccination. vaccine response vaccine-induced antibody response widespread [DOI] 10.1016/j.celrep.2022.111022 PMC 바로가기 [Article Type] Article
Seroprevalence of Anti-S1-RBD Antibodies in Pre-pandemic and Pandemic Subjects From Hail Region, KSA우박 지역, KSA의 전염병 전 및 전염병 대상체에서 항-S1-RBD 항체의 혈청유병률Article Published on 2022-06-092022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] age antibodies antibody level antibody levels Antigen asymptomatic individual Asymptomatic individuals Care clinical and demographic factors clinically collected complications Containment COVID-19 Demographic factors develop Efficacy effort ELISA exhibited exposure to female females group Hail house humoral immune responses identification immune responses in-house ELISA Infection male management neutralizing antibody new SARS-CoV-2 other coronavirus other coronaviruses pandemic positive Protein RBD antigen reduced Region required Research S-RBD S1-RBD Sample SARS-CoV-2 Screen Seroprevalence seroprevalence. serum serum antibodies serum antibody serum IgG antibodies serum IgG antibody significantly significantly higher subject Surveillance the SARS-CoV-2 Vaccine variant variants [DOI] 10.3389/fpubh.2022.874741 PMC 바로가기 [Article Type] Article
Protein engineering responses to the COVID-19 pandemic코로나19 팬데믹에 대한 단백질 공학 대응Review Published on 2022-06-012022-09-11 Journal: Current opinion in structural biology [Category] COVID19(2023년), SARS, 변종, [키워드] Antigen breadth candidate COVID-19 COVID-19 pandemic COVID-19 vaccine develop display elicited glycoprotein High-resolution human population Humoral immunity nanoparticle neutralization potency other coronavirus other coronaviruses PROTECT researcher response robust SARS-CoV-2 variant SARS-CoV-2 variants Structure structure-based design Substitution vaccine candidate [DOI] 10.1016/j.sbi.2022.102385 PMC 바로가기 [Article Type] Review
Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers고유한 서열 식별자를 식별하는 생물정보학 도구인 LeTRS를 사용하여 세포 배양, 동물 모델 및 임상 샘플에서 SARS-CoV-2 알려진 및 신규 서브게놈 mRNA 분석Article Published on 2022-05-262022-09-11 Journal: GigaScience [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus animal model animal models bioinformatics Biology biology of SARS-CoV-2 can be used Cell Cell culture clinical sample clinical samples complex coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 data set diagnostics Direct RNA sequencing Each evaluate generate host response identify implication in some indicated Infection junction longitudinal samples mammalian mechanism medical countermeasure Medical countermeasures Middle East Middle East respiratory syndrome Coronavirus multiphasic Nanopore nasopharyngeal sample nucleic acid open reading frames other coronavirus other coronaviruses Patient plasticity provide Quantitative reflected Regulatory respiratory syndrome coronavirus RNA RNA modification SARS-CoV-2 selection pressure sequence Sequencing sequencing data severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sgmRNA sgmRNAs subgenomic mRNA subject target targets Transcription transcriptional regulatory sequences transcriptional regulatory sequences. Transmission model unique variant Viral RNA viral RNA synthesis virus was tested [DOI] 10.1093/gigascience/giac045 PMC 바로가기 [Article Type] Article